Viking Therapeutics (VKTX:NGS) — Buy The Rumor, Buy The News

https://seekingalpha.com/article/4128751-viking-therapeutics-buy-rumor-buy-news

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Viking Therapeutics (VKTX) announced top-line results for its Phase II trial of VK5211 on Nov-28th. Headline data was positive with the study achieving its primary endpoint of demonstrating statistically significant, dose-dependent increases in lean body mass (less head) in all dosage arms, and with zero drug-related serious adverse events (SAEs) being reported.

VK5211 is a powerful selective androgen receptor modulator (SARM) that is being positioned clinically as a potential best-in-class therapy for improving muscle and bone growth. The trial was based around the drug’s initial target indication of elderly patients recovering from a hip fracture – a large, underserved market in which there are approx. 300k hospitalizations per year in the U.S. alone. The trial launched in late 2015 and, after various delays in recruiting patients, was finally completed in summer 2017. The 108-person study was designed to assess increases in lean body mass and was divided into three treatment arms: 0.5mg, 1.0mg, and 2.0mg, as well as a placebo group…

 

 

 

 

 

 

 

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Viking Therapeutics (VKTX:NGS) — FY’17 Q3 Quarterly Update

https://seekingalpha.com/article/4122928-viking-therapeutics-fy17-q3-quarterly-update

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Viking Therapeutics (VKTX) reported Q3’17 results on Nov-8th after market-hours. Headline results showed a slight earnings “miss” in the quarter as a result of a non-cash charge, however this remains essentially irrelevant in context of both the near-term and long-term investment thesis as the company awaits the release of top-line data from its phase II trial on molecule VK5211. Shares have essentially traded flat since the quarterly release in the $2.20 range; and while this is down materially from the $3+ price level achieved in mid-October, is still higher by ~100% from the summer months…

 

 

 

 

 

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Viking Therapeutics (VKTX:NGS) — Welcome To The Glorious House of Gains

Viking Therapeutics: Welcome to the Glorious House of Gains

  • Viking Therapeutics is a clinical-stage biotech company that is focused on developing novel therapies to various acute and chronic metabolic and endocrine disorders
  • A spin-off of Ligand Pharmaceuticals in 2015, Viking maintains a pipeline of four molecular candidates held under an exclusive Master License Agreement. Clinical studies target a broad range of indications to large, underserved markets.
  • Lead candidate VK5211 is a potent Selective Androgen Receptor Modulator (SARM). Extensive history of efficacy from early clinical trials in animals/humans, as well as testimonials from (illegal) recreational usage as a black-market PED by athletes/bodybuilders.
  • Currently conducting a Phase II trial for post-operative, hip fracture rehabilitation support in elderly patients. Top-line data expected Q4’17; and recently held panel discussion to outline regulatory steps towards commercialization of $1b+ addressable market.
  • With funding secure through mid-2018, Viking has line-of-sight on multiple upcoming catalysts over the course of the next 6-12 months that could position the stock to have significant potential upside.  

Introduction

One of the greatest internet personalities (celebrities?) is the indomitable RobertFrank615.

For the uninitiated, he is a real-life, pumped-up, Jersey Shore gym rat who is essentially playing a caricature of himself. Loaded with an army of nearly 650k followers, he creates off-kilter, motivational videos that he posts to Instagram and YouTube.

Put simply, his character’s goal in life is to make huge “gainz” at the gym in order to get a “sick pump” for the weekend to then be able to pick up women. In real life (“IRL”) though, he co-stars in many of the short videos with his fiancée (yes, it’s adorable) and just seems to be a genuine guy that happens to be jacked as all heck and loves to work out.

He’ll dance to forget the haters. He absolutely despises leg day; and he often comes up with highly entertaining creative expressions such as International Chest Day (i.e. Mon-Thurs) or my favorite, the Glorious House of Gains (i.e. the gym).

He also happens to be the perfect pop-culture reference for an investment in Viking Therapeutics (VKTX:NGS) for two reasons:

  1. Viking’s lead candidate—a molecule known as VK5211–is a potent SARM that has been used as a black-market performance enhancement drug (PED) by athletes and bodybuilders. It is now being positioned clinically as a potential best-in-class treatment for a wide assortment of acute and chronic muscle and bone loss.
  1. It’s initial area of exploration—rehabilitation support to post-operative elderly patients that suffered a hip fracture—is currently engaged in a Phase II trial, with top-line data expected to be released in Q4’17. With funding secure through mid-2018, to the extent its successful it should propel the stock forward as a major proof of concept towards commercialization.

Said another way, investors in Viking Therapeutics may be positioning—literally and figuratively—to enter into the GLORIOUS HOUSE OF GAINS on the back of positive top-line data from the VK-5211’s Phase II trial results due out later this year.

But I may be getting ahead of myself…

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Full Report

 

 

 

 

 

 

 

 

 

Nvidia (NVDA:NGS) — Choosing To Sit This One Out

Nvidia: Choosing To Sit This One Out

  • Nvidia is a wonderful business.
  • It is a top designer of GPUs for the PC-gaming and Professional Visualization markets. It also continues to deliver exceptional growth in Datacenter due to the rise of “GPU Computing”.
  • But take heed of forecasts that Nvidia is the “it” company for machine-learning! The future is decidedly ASIC and it remains questionable whether GPUs will power the next-generation of AI.
  • The proprietary CUDA API is the difference between a generational growth stock and a bubble.
  • Idiosyncratic growth has been beyond impressive, but risks abound. I choose to sit this one out… an active decision.

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The Good, the Bad and the Caveat

Let me start by saying that Nvidia (NVDA:NGS) is a wonderful business. The company has maintained a leading franchise within the high-end PC graphics card market for almost 20 years. It dominates the market for Professional Visualization with engineering CAD-software renderings; and it continues to deliver on its outstanding growth from Datacenter due to the secular trends in cloud computing and machine learning.

It has leveraged this growth into an enviable financial profile. The company’s earnings growth has resembled that of a hockey stick, while its balance sheet remains exceedingly strong. It is still firing on all cylinders as it maintains a cadre of top-notch engineers being led by its visionary founder; and it appears poised to exceed relatively pacified growth expectations through at least the rest of this year.

So, I understand what the fuss is about. I see the reason pundits such as Cramer, the brothers Najarian, and the investment public at large continue to fawn over it. But Nvidia has also turned into the “can’t miss” stock of a “can’t miss” technology boom.

Yet risks abound as the company is a prime beneficiary of hype and misunderstanding. The untold stories of the CUDA API, matrix multiplication, and the Fourier Transform, which are aspects not readily discussed by cheerleader sell-side research reports and on networks such as CNBC.

These are abstract concepts for a retail investor base that still largely believes thread-counts have more to do with bedding than machine learning.

This is not an indictment though. I am not short. I am not long. I have no horse in the race. I merely find the company to be un-investable at current price levels for the non-speculator; and have simply decided to sit this one out.

So why publish at all then? What’s even the point?

Because clients, friends and family seem to ask about it every day… and because I no longer have a choice.

Sitting this one out has become an active decision…

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Full Report

 

 

 

 

 

 

 

Nvidia (NVDA:NGS) — Choosing To Sit This One Out

Nvidia: Choosing To Sit This One Out

  • Nvidia is a wonderful business.
  • It is a top designer of GPUs for the PC-gaming and Professional Visualization markets. It also continues to deliver exceptional growth in Datacenter due to the rise of “GPU Computing”.
  • But take heed of forecasts that Nvidia is the “it” company for machine-learning! The future is decidedly ASIC and it remains questionable whether GPUs will power the next-generation of AI.
  • The proprietary CUDA API is the difference between a generational growth stock and a bubble.
  • Idiosyncratic growth has been beyond impressive, but risks abound. I choose to sit this one out… an active decision.

— — —

The Good, the Bad and the Caveat

Let me start by saying that Nvidia (NVDA:NGS) is a wonderful business. The company has maintained a leading franchise within the high-end PC graphics card market for almost 20 years. It dominates the market for Professional Visualization with engineering CAD-software renderings; and it continues to deliver on its outstanding growth from Datacenter due to the secular trends in cloud computing and machine learning.

It has leveraged this growth into an enviable financial profile. The company’s earnings growth has resembled that of a hockey stick, while its balance sheet remains exceedingly strong. It is still firing on all cylinders as it maintains a cadre of top-notch engineers being led by its visionary founder; and it appears poised to exceed relatively pacified growth expectations through at least the rest of this year.

So, I understand what the fuss is about. I see the reason pundits such as Cramer, the brothers Najarian, and the investment public at large continue to fawn over it. But Nvidia has also turned into the “can’t miss” stock of a “can’t miss” technology boom.

Yet risks abound as the company is a prime beneficiary of hype and misunderstanding. The untold stories of the CUDA API, matrix multiplication, and the Fourier Transform, which are aspects not readily discussed by cheerleader sell-side research reports and on networks such as CNBC.

These are abstract concepts for a retail investor base that still largely believes thread-counts have more to do with bedding than machine learning.

This is not an indictment though. I am not short. I am not long. I have no horse in the race. I merely find the company to be un-investable at current price levels for the non-speculator; and have simply decided to sit this one out.

So why publish at all then? What’s even the point?

Because clients, friends and family seem to ask about it every day… and because I no longer have a choice.

Sitting this one out has become an active decision…

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https://seekingalpha.com/article/4085429-nvidia-choosing-sit-one